A new therapeutic approach is being developed for the treatment of Alzheimer's disease (AD). This approach involves the deliberate induction of an autoimmune response to amyloid‐β (Aβ) peptide, the constituent of neuritic plaques that is thought to cause the neurodegeneration and dementia in AD. If this approach is to be effective, antibodies must be produced that can selectively target the toxic forms of Aβ, while leaving the functionally‐relevant forms of Aβ and its precursor protein untouched. Furthermore, an approach needs to (...) be found that avoids provoking an acute neuroinflammatory response. The situation is made even more challenging by uncertainty regarding which isoforms of Aβ contribute to the pathogenesis of AD. BioEssays 25:283–288, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

A new therapeutic approach is being developed for the treatment of Alzheimer's disease (AD). This approach involves the deliberate induction of an autoimmune response to amyloid‐β (Aβ) peptide, the constituent of neuritic plaques that is thought to cause the neurodegeneration and dementia in AD. If this approach is to be effective, antibodies must be produced that can selectively target the toxic forms of Aβ, while leaving the functionally‐relevant forms of Aβ and its precursor protein untouched. Furthermore, an approach needs to (...) be found that avoids provoking an acute neuroinflammatory response. The situation is made even more challenging by uncertainty regarding which isoforms of Aβ contribute to the pathogenesis of AD. BioEssays 25:283–288, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Trust is an attitude that an agent (the trustor) has toward an entity (the trustee), such that the trustor counts upon the trustee to act in a way that is benefi- cial w.r.t. to the trustor’s goals. The notion of trust is relevantly discussed both in in- formation science and philosophy. Unfortunately, we still lack a satisfying account for this concept. The goal of this article is to contribute to filling this gap. First, we take issue with some central tenets (...) shared by the main philosophical accounts, such as that there is just one relation of trust, that this relation has three argument places, and that trust is reliance plus some extra factor. Second, we provide a novel account of trust, also discussing different levels of trust. According to the account we put forth here, the logical form of trust sentences is expressed by a four-place relation. Further, we distinguish and characterize four kinds of trust relations and their connections. We also argue that trust and reliance are different phenomena. Third, on the basis of the proposed account, we extend the Reference Ontology of Trust (ROT). We call the new version of ROT that includes this extension ”ROT 3.0”. Finally, we discuss the implications of the new ontological definitions in the applications we have done of the concept of trust in other works, also pointing out future applications made possible by these novel accounts of trust. (shrink)

Some of the ways in which the experience of mothering is shaped by the moral and cultural constructions surrounding breastfeeding discourse are examined using a critical deconstruction of recent Canadian health education material. Connections between the understandings surrounding breastfeeding and cultural constructions of nature and sexuality are raised, as is the overlap between breastfeeding discourse and a number of other social discourses including those surrounding child-centered parenting expertise, the remoralization of pregnancy, and the neoliberal preoccupation with individual responsibility and the (...) cost of social programs. Some of the implications that this understanding poses for mothers are examined. (shrink)

We argue that if a different definition of sentence complexity is adopted and processing capacity is assessed in a way that is consistent with that definition, then the Caplan & Waters distinction between interpretive versus postinterpretive processing is unnecessary insofar that it applies to the thematic role assignment in relative-clause sentences.

Constructing a dialogue between the social theory of Alain Touraine and the philosophy of Paul Ricoeur, this work locates the wellsprings of the renewed intepretative powers of Touraine's recent sociology of the subject and critique of modernity in an implicit and unfinished, but unmistakable 'hermeneutical turn'.

BackgroundResearch has demonstrated that exposure to suicide can lead to increased vulnerability for self-harm or suicide. As a result, ideation-to-action models of suicide recognise exposure as a significant risk factor which may be implicated in the translation of thoughts into actions. However, few studies have tested this theoretical link explicitly within an adolescent population, and examined how it compares to other types of bereavements.MethodsA 6-month prospective questionnaire study was conducted with 185 Scottish adolescents aged 11–17. The questionnaire included measures on (...) experiences with bereavement and lifetime engagement in self-harm, as well as measures of defeat, entrapment, social support, coping, and other psychological variables.ResultsAt baseline, 11% of young people reported exposure to a suicide death, and 62% to a non-suicide death. In addition, 21% of pupils reported ever engaging in self-harm, while 24% had experienced self-harm ideation without engaging in it. Cross-sectional multivariate logistic regressions showed that maladaptive coping, family social support, glorifying/normalising beliefs about suicide, and family self-harm were significantly associated with self-harm group membership. At follow-up, 9% of pupils reported exposure to a suicide death and 11% to a non-suicide death for the first time. A total of 29% of the sample reported self-harm at T2, and 23% reported self-harm ideation without engaging in it. Multivariate analyses found that stigmatising beliefs about suicide, glorifying/normalising beliefs about suicide, and self-harm ideation at baseline were the only variables to predict self-harm group membership prospectively. Bereavement experiences, whether by suicide or non-suicide, did not predict self-harm group status at baseline nor at follow-up.ConclusionsThis study provides support for the validity of a theoretical model of suicide, even though predictive ability over the 6-months period was limited. Although difficulties with recruitment may have limited the statistical power, this study provides insight into the prevalence and experiences of suicide bereavement among adolescents and the factors related to the onset and maintenance of self-harm. (shrink)

Розкрито сутність поняття «рейтинг». Доведено значущість рейтингової оцінки для суб’єктів фінансового ринку, зокрема для страхових компаній, потенційних страхувальників, інвесторів та кредиторів.

In this article we offer a single case study using an action research method for gathering and analysing data offering insights valuable to both design and research supervision practice. We do not attempt to generalise from this single case, but offer it as an instance that can improve our understanding of research supervision practice. We question the conventional ‘dyadic’ models of research supervision and outline a more collaborative model, based on the signature pedagogy of architecture: the design studio. A novel (...) approach to the supervision of creatively oriented postgraduate students is proposed, including new approaches to design methods and participatory supervision that draw on established design studio practices. This model collapses the distance between design and research activities. Our case study involving Master's Research Students supervision in the discipline of Architecture, shows how ‘connected learning’ emerges from this approach. This type of learning builds strong elements of creativity and fun, which promote and enhance student engagement. The results of our action research suggest that students learn to research more easily in such an environment and supervisory practices are enhanced when we apply the techniques and characteristics of design studio pedagogy to the more conventional research pedagogies imported from the humanities. We believe that other creative disciplines can apply similar tactics to enrich both the creative practice of research and the supervision of HDR students. (shrink)

A textbook of language study for trainee teachers.

Abstract The introduction of genetically modified plants into the environment has been marked by different positions, either in favor of or against their release. However, the problem goes well beyond such contradictory positions; it is necessary to take into account the legislation, ethics, biosafety, and the environment in the considerations related to the release of genetically modified organisms (GMOs). To this end, the Brazilian Committee of Biosafety (CTNBio), a consultative and deliberative multidisciplinary collegiate, provides technical and advisory support to the (...) Brazilian Federal Government. This committee consists of scientists and non-scientists who participate in evaluating the dossiers of companies that are requesting approval by the Brazilian Government; consequently, the aim of this study was to investigate whether commercial approvals of GMOs were associated with the profile of the CTNBio members. Research was based on the minutes taken at CTNBio meetings carried out from 2006 up to 2009, considering law 11.105/2005 and the Constitution of 1988 as legal frameworks, to determine the number of voters in favor of or against releasing genetically modified Bt-maize, Bt-cotton, and herbicide resistant soybeans to be used in Brazilian agriculture. Via the internet, we had access to the curriculum vitae of the CTNBio members through the Plataforma Lattes database of the National Council for Scientific and Technological Development (CNPq), where we found their area of expertise. CTNBio members were divided into expert-for, expert-against, non-expert-for, and non-expert-against. Results showed that CTNBio decisions could be based on technical criteria as well as on the policy of the institution that expert-members were representing. Content Type Journal Article Category Articles Pages 1-11 DOI 10.1007/s10806-011-9347-x Authors Glenda Morais Rocha Braña, Programa de Pós-Graduação em Bioética da Cátedra/UNESCO, Faculdade de Ciências da Saúde, Universidade de Brasília, Brasília, DF, Brazil Ana Luisa Miranda-Vilela, Departamento de Genética e Morfologia, Laboratório de Genética Toxicológica, Instituto de Ciências Biológicas, Universidade de Brasília, Brasília, DF, Brazil Cesar Koppe Grisolia, Departamento de Genética e Morfologia, Laboratório de Genética Toxicológica, Instituto de Ciências Biológicas, Universidade de Brasília, Brasília, DF, Brazil Journal Journal of Agricultural and Environmental Ethics Online ISSN 1573-322X Print ISSN 1187-7863. (shrink)

Se presenta una experiencia de formación docente implementada en contexto de innovación curricular, proceso desarrollado a nivel nacional en las instituciones del Consejo de Rectores de Universidades de Chile (CRUCH). Esta experiencia, se realizó durante el año 2017, con la implementación de la Capacitación “Metodologías Activas Para el Desarrollo de Competencias”, del Centro de Mejoramiento Docente de la Universidad de Atacama, y tuvo como principal objetivo, determinar el grado de contribución a la implementación del proceso enseñanza – aprendizaje, desde la (...) percepción de docentes y directivos, de las carreras de Pedagogías de la Facultad de Humanidades y Educación, de la UDA. (shrink)

Brazil is the biggest market for pesticides in the world. In the registration process, a pesticide must be authorized by the Institute of the Environment, Health Surveillance Agency and Ministry of Agriculture. Evaluations follow a package of toxicological studies submitted by the companies and also based on the Brazilian law regarding pesticides. We confronted data produced by private laboratories, submitted to the Institute of the Environment for registration, with data obtained from scientific databases, corresponding to mutagenicity, carcinogenicity and teratogenicity of (...) pesticides. All studies submitted by the companies were carried out by private laboratories. From 247 pesticide formulations analyzed, none showed positive results for mutagenicity, carcinogenicity or teratogenicity. From 574 articles in the scientific literature, 84% published by public laboratories showed positive results, while 79% of those showing negative results came from private laboratories. There is an ethical concern about a conflict of interest between public/independent laboratories and private laboratories that produce data for registering pesticides. We demonstrated that there is a clear contradiction between public and private laboratories. Brazilian regulatory authorities have approved the registration of pesticides based almost exclusively on the monographs provided by the pesticide industry, because the use of scientific articles or information from the independent literature is strongly belittled by the industry. Pesticide companies argue that scientific articles cannot be trusted. Also, according to the industry, pesticide registration cannot be refused based on results from scientific articles. Thus, the registration of pesticides with mutagenic, carcinogenic and teratogenic risks has been approved in Brazil. (shrink)

Enactivists claim that social cognition is constituted by interactive processes and even more radically that there is ‘no observation without interaction’. Nevertheless, the notion of interaction at the core of the account has not yet being characterized in a way that makes good the claim that interactions actually constitute social understanding rather than merely facilitating or causally contributing to it. This paper seeks to complement the enactivist approach by offering an account of basic joint action that involves and brings with (...) it basic forms of mental understanding. The paper turns to theories of joint action rather than theories of perception as some enactivists have done :535–543, 2008; Thompson in J Conscious Stud 8:1–32, 2001), to gain insight into the kind of interactions that underpin our understanding of other minds, and in that way, supplement the interactionist-enactive account. In line with Enactivism, the paper argues that this kind of social understanding is practical rather than theoretical and that it is cognitively more basic and developmentally prior when compared to other ways we come to understand other minds. (shrink)

The paper presents two empirical cases of expert musicians—a classical string quartet and a solo, free improvisation saxophonist—to analyze the explanatory power and reach of theories in the field of expertise studies and joint action. We argue that neither the positions stressing top-down capacities of prediction, planning or perspective-taking, nor those emphasizing bottom-up embodied processes of entrainment, motor-responses and emotional sharing can do justice to the empirical material. We then turn to hybrid theories in the expertise debate and interactionist accounts (...) of cognition. Attempting to strengthen and extend them, we offer ‘Arch’: an overarching conception of musical interaction as an externalized, cognitive scaffold that encompasses high and low-level cognition, internal and external processes, as well as the shared normative space including the musical materials in which the musicians perform. In other words, ‘Arch’ proposes interaction as a multivariate multimodal overarching scaffold necessary to explain not only cases of joint performance, but equally of solo improvisation. (shrink)

Tuberculosis en América Latina y el Caribe: reflexiones desde la bioética Tuberculose na América Latina e no Caribe: reflexões da bioética The objective of this article is to analyze the conditions of access to health services by people with tuberculosis in Latin America and the Caribbean, reflecting on the public health aspects involved from a bioethical perspective. A literature review of the context of tuberculosis in LAC based on epidemiological data was performed. The results were analyzed from its relationship with (...) the social determinants of health and the ethical principles that guide medical practice. Tuberculosis is a pressing public health problem in the region because of its family, social, economic and health impact. It mainly affects vulnerable individuals and populations. Health services violate ethical principles. Tuberculosis is a serious ethics and public health problem in the region that causes death, disability and increased poverty. It is imperative to ensure the right to health services and to understand the individual and public health consequences of non-adherence to treatment. It is important that national tuberculosis control strategies include principles of dignity and non-discrimination of the sick, changes in the social determinants of the disease, and respect for the ethnicity, language culture and identity of patients. Para citar este artículo / To reference this article / Para citar este artigo Muñoz del Carpio-Toia A, Sánchez-Pérez HJ, Verges de López C, López-Dávila LM, Sotomayor-Saavedra MA, Sorokin P. Tuberculosis en América Latina y el Caribe: reflexiones desde la bioética. pers. bioét. 2018; 22: 331-357. DOI: 10.5294/pebi.2018.22.2.10. (shrink)

We review the current state of play in the game of naturalizing content and analyse reasons why each of the main proposals, when taken in isolation, is unsatisfactory. Our diagnosis is that if there is to be progress two fundamental changes are necessary. First, the point of the game needs to be reconceived in terms of explaining the natural origins of content. Second, the pivotal assumption that intentionality is always and everywhere contentful must be abandoned. Reviving and updating Haugeland’s baseball (...) analogy in the light of these changes, we propose ways of redirecting the efforts of players on each base of his intentionality All-Star team, enabling them to start functioning effectively as a team. Only then is it likely that they will finally get their innings and maybe, just maybe, even win the game. (shrink)

This paper introduces the Special Issue: ‘The Roots of Normativity. Developmental, Comparative and Conceptual issues’. The contributions collected in this volume aim to present a picture of contemporary accounts of normativity that integrate philosophy and developmental and comparative psychology and purport to provide the reader with new insights regarding a classical debate about what makes us human: being governed by norms and being able to orient ourselves in the light of them. This introduction presents a broad picture of the issues (...) at the heart of traditional discussions on normativity and lays out a set of conditions which a proper account of normativity should meet. In so doing the main common themes that unify these papers are brought to the fore. In particular, all of them share the idea that human-specific norms are themselves social. Once questions concerning the evolution of normative capacities and their development are considered, however, they pose - so it is argued - specific challenges to an account of normativity. While the traditional approaches fail to face such challenges, it is the main aim of the papers in this Special Issue to meet them. In concluding, a brief overview of each paper is provided. (shrink)

"Williams's masterful translation satisfies (at last!) a long-standing need. There are lots of good translations of Augustine's great work, but until now we have been forced to choose between those that strive to replicate in English something of the majesty and beauty of Augustine's Latin style and those that opt instead to convey the careful precision of his philosophical terminology and argumentation. Finally, Williams has succeeded in capturing both sides of Augustine's mind in a richly evocative, impeccably reliable, elegantly readable (...) presentation of one of the most impressive achievements in Western thought--Augustine's Confessions." --Scott MacDonald, Professor of Philosophy and Norma K. Regan Professor in Christian Studies, Cornell University. (shrink)

While popular cultural representations portray the “new father” of the past two decades as more involved, more nurturing, and capable of coparenting, many argue that actual fathering conduct has not kept pace. Others, however, question the extent to which the culture of fatherhood does indeed support involved fathering and, if so, what this involvement entails. This study aims to contribute to the exploration of the culture of fatherhood through an analysis of a yearlong Canadian newspaper series dedicated to family issues. (...) Findings suggest that through representations of parental guilt, parental responsibility, work—family balance issues, and hegemonic masculinity, mothers continue to be positioned as primary parents. Support for father involvement, to the extent that it exists, occurs within the framework of fathers as part-time, secondary parents whose relationship with children remains less important than mothers'. (shrink)

Cultivated by Hand aligns the overlooked history of amateur musicians in the early years of the United States with little-understood practices of music book making. It reveals the pervasiveness of these practices, particularly among women, and their importance for the construction of gender, class, race, and nation.

At the turn of the twenty-first century, historical studies of internationalism--above and beyond the call to the workers of the world to unite--have become the norm in a relatively short space of time. This shift has occurred in the context of a historical vogue for 'transnationalism,' that is, capturing experiences that traversed and transcended the borders of nation-states both within and beyond the European world. The work of the diplomatic historian Akira Iriye has been central to these developments, illuminating the (...) traces of a distinctively twentieth century history of 'cultural internationalism' that resonated through the realms of politics. Following in the footsteps of Iriye and others--including feminist and pacifist historians who had long engaged the internationalist past--a new cohort of international historians, often sensitive to cultural analyses and with expertise in imperial and transnational as well as national histories, are now accruing broad-ranging evidence of the geographies of internationalism and the political and economic reach of its various strands at critical moments in the twentieth century. (shrink)

SummaryThis essay provides an overview of the disciplinary and analytical significance of David Armitage's Foundations of Modern International Thought in the context of the new international history, and the so-called ‘international turn’. It then goes on to discuss the significance of the absence of women in this new sub-field of intellectual history.

Even if it appears quite evident that we live within society and as a consequence are bound together by shared norms and institutions, the nature of this relationship is a source of philosophical perplexity. After discussing the conditions of adequacy a conception of shared norms must accommodate, I discuss communitarian and interpretationist accounts of shared norms. I claim that they are problematic insofar as they fail to provide an adequate conception of the shared and binding character of social norms. Finally, (...) I argue that a different understanding of the shared character of norms follows from a correct understanding of the conditions of adequacy at stake. (shrink)

To address the tension between demands for more transparent AI systems and the aim to develop and design robots with apparent agency for smooth and intuitive human-robot interaction (HRI), we present in this paper an argument for why explainability in HRI would benefit from being question-centered. First, we review how explainability has been discussed in AI and HRI respectively, to then present the challenge in HRI to accommodate the requirement of transparency while also keeping up the appearance of the robot (...) as a social agent. Based on the conceptualization of questions as information-seeking acts, our proposal for a question-centered approach to explainable HRI (xHRI) implies that to ensure transparency, robots shall provide explanations upon request in the form of questioning. We end this paper by laying out a preliminary taxonomy of xHRI-relevant questions that present the kinds of explanations a robot can or should be able to provide for successful and transparent HRI. (shrink)